Summary: We compare the side effects and drug effectiveness of Humira and Sulfasalazine. Throwing Up It is very important that your doctor check your or your child's progress at regular visits. headaches. Manufacturer: PHARMACIA / UPJHN. Appetite loss 6. Sulfasalazine has also been used for some skin conditions. Learn from their experiences about effectiveness, side effects and cost. fever All rights reserved. (sul fa sal’ a zeen). Absorption The more common side effects that can occur with sulfasalazine include: You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. Sulfasalazine comes as regular and delayed-release (enteric-coated) tablets. When you begin taking this medicine: If you have a severe reaction from the sun, check with your doctor. Early treatment of rheumatoid arthritis with sulfasalazine helps to reduce and even prevent further joint damage so you can do more of your normal daily activities. If any of these effects persist or worsen, notify your doctor or … Sulfasalazine was approved by the Food and Drug Administration in 1950. Name: SULFASALAZINE Strength(s): 500 MG Aching of joints 2. Some side-effects you should let your doctor know about straightaway - these include any unexplained bleeding, bruising, itchy skin rash, difficulties breathing, sore throat, … ... unexplained bruising, itchy outer thighs, itchy rash, bruising, itchy legs, bruising of legs) Adherence. Diarrhea 3. Distributor: WAL MART STORES INC. They are specially formulated to release the medication after they have passed through your stomach. However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Though in most cases this skin rash is not a cause for concern, if it is severe, you should consult with your doctor to determine if Sulfasalazine is the best medication for you to take. What special precautions should I follow? Dizzy 4. This means that it is not expected to harm an unborn baby. Diarrhea 3. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. Side effects can occur earlier. Continue to take sulfasalazine and talk to your doctor if you experience: nausea, vomiting, or decreased appetite NRAS. Indigestion 7. Summary: We compare the side effects and drug effectiveness of Sulfasalazine and Enbrel. Saw GP who suggested that this was the cause recommended I stopped taking the medication & gave me a course of antihistamine contacted my Rheumy who agreed with the course of action. Headache 5. When taking Sulfasalazine, reported side effects are usually mild and improve in time. Take sulfasalazine exactly as directed by your doctor. Advertising revenue supports our not-for-profit mission. Your doctor may want to monitor the digoxin levels in your blood if you are taking this medicine. Sulfasalazine may cause side effects. no side effects. The delayed-release tablets, Azulfidine® (EN-tabs), are also used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. Distributor: PHYSICIANS TOTALCARE INC. Name: SULFASALAZINE Strength(s): 500 MG Also common are indigestion, nausea and watery diarrhoea, as well as mild allergic reactions such as rash, itchiness and … Please do not take a double dose of this medication. headache A prescription is required for this medicine. SULFASALAZINE IS a common therapeutic drug used to treat inflammatory bowel disease, rheumatoid arthritis, and psoriatic arthritis. Please read them carefully. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis. This medication is used together with other drugs, rest, and physical therapy in patients who have not responded to other medications (such as salicylates and nonsteroidal anti-inflammatory drugs [NSAIDs]). Side effects other than those listed here may also occur. Fertility returns when the medicine is stopped. This is normal and nothing to worry about. The most common side effect of sulfasalazine is headache, and this is the main reason why some patients cannot take the drug. These may be signs that you have an infection. Sulfasalazine is used to treat ulcerative colitis and to maintain remission. Trouble breathing 14. Please remember to throw away any medication that is outdated or no longer needed. The study is created by eHealthMe based on reports (from sources including the FDA) of 565,476 people who take Humira and Sulfasalazine, and is updated regularly. Abnormal Urine Color 2. Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible. Copyright © 2020 IBM Watson Health. You may not be able to take sulfasalazine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. These side effects usually happen during the first three months of treatment and often clear up if the dose is lowered. A severe adverse reaction to sulfasalazine has been identified as a type of hypersensitivity syndrome. Manufacturer: QUALITEST. This medication works by reducing irritation and swelling in the large intestines. It is very important to continue taking sulfasalazine to control your condition. In the case of an overdose, call your local poison control center on 1-800-222-1222. Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine. Upset stomach 2. yellow skin or eyes (may indicate a blood disorder). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Stomach Cramps 11. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn’s disease. Apply a sun block product that has a skin protection factor (SPF) of at least 15. Sulfasalazine helps to reduce joint pain, swelling, and stiffness. Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. Toxic epidermal necrolysis, Stevens-Johnson syndrome, drug rash with eosinophilia and systemic symptoms (DRESS), acute generalised exanthematous pustulosis, and drug induced erythroderma are important differential diagnoses in patients with acute rash after drug exposure. Imprint: G 500 pale skin Call your doctor right away if you start to have a cough that won't go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Sulfasalazine may decrease the absorption of digoxin (Lanoxin®, Lanoxicaps®). If you have any questions about this, check with your health care professional. Pee that is dark 13. Name: AZULFIDINE EN-TAB® Sulfasalazine is sold under the brand name Azulfidine® in the United States. Commonly these include loss of appetite, nausea, headache, and rash. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Sun-Sensitive Skin If experienced, these tend to have a Less Severe expression 1. Mayo Clinic does not endorse companies or products. If experienced, these tend to have a Severe expression 1. Dental work should be delayed until your blood counts have returned to normal. decreased sperm production (uncommon and usually reversible) © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. Never taken as prescribed Burden. Head ache 17. The enteric-coated formulation of Azulfidine EN-tabs® was specifically designed to reduce the likelihood of nausea and stomach upset. Azulfidine Consumer Information. Your skin or urine may turn an orange or yellow color while you or your child are using this medicine. This will allow your doctor to check if the medicine is working properly. Drugs other than those listed here may also interact with sulfasalazine. Tell your doctor if you have any kind of infection before you start using this medicine. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter. Manufacturer: GREENSTONE LTD. Apply a sun block lipstick that has an SPF of at least 15 to protect your lips. Below you will find images and specific information on the principal types of sulfasalazine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors. Take the missed dose as soon as you remember. Sulfasalazine may also be used to treat stomach pain, rectal bleeding, diarrhea caused by Crohn’s disease, and back pains and inflammation (ankylosing spondylitis). rashes. orange-yellow discoloration of the skin or urine (not harmful). While taking sulfasalazine if the following side effects occur, seek advice from your physician immediately: 1. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea) Sulfasalazine Side Effects Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. Aching of muscles black, tarry stools blistering, peeling, or loosening of the skin bloating blood in the urine or stools bloody diarrhea bluish fingernails, lips, or skin chest pain constipation cough difficulty with swallowing dizziness fainting spells fast heartbeat … Fever Caused By Administration Of A Drug 2. Find reviews for Sulfasalazine from other patients. What storage conditions are needed for this medicine? These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Currently, this drug is approved by the US Food and Drug Administration (FDA) for the treatment of ulcerative colitis and rheumatoid arthritis. Brand Name(s): Azulfidine; Azulfidine EN-tabs; Salazopyrin; SAS-500 What are the common or serious side effects of sulfasalazine? This medicine may increase your risk of developing infections. Sulfasalazine may also decrease folate (a natural vitamin) in your body. Distributor: MAJOR PHARMACEUTICALS. Portions of this document last updated: Dec. 01, 2020. Head Pain 6. The safety and effectiveness of sulfasalazine have not been established for children younger than 2 years of age. Like all DMARDs, sulfasalazine takes time to work. Do not take sulfasalazine without first talking to your doctor if you have ever had an allergic reaction to sulfasalazine, a sulfa-based antibiotic, or aspirin; an obstruction (blockage) in your intestines or urinary tract; porphyria; liver disease; kidney disease; asthma; or glucose-6-phosphate dehydrogenase deficiency. Sulfasalazine oral tablet may cause drowsiness. If you plan to have children, talk with your doctor before using this medicine. CAS nº: 599-79-1 The sections below will provide you with more specific information and guidelines related to sulfasalazine and its correct use. Strength(s): 500 MG Blood and urine tests will be needed to check for unwanted effects. Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase. Common side effects — The most common side effects of sulfasalazine are headache, nausea, fever, rash, and reversible infertility in men. More common side effects. Common side effects may include: nausea, vomiting, upset stomach, loss of appetite; headache; rash; or low sperm count in men. Imprint: MP 91 The present article is a detailed review of the pharmacology, modes of action, side effects, and contraindications of sulfasalazine, along with an up-to-date review of the evidence underlying its use in various dermatological conditions. Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Sulfasalazine side effects: Hi Everyone I am on my... - NRAS. If you have any questions, talk to your pharmacist about the proper disposal of your medication. Sulfasalazine is in the FDA pregnancy category B. Wash your hands often. seizures. Do not use a sunlamp or tanning bed or booth. - Rash had the appearance of an exfoliative dermatitis bordering on a SJ syndrome (diffuse MP rash with an erythematous/scaly background); there were no oral lesions. Do not stop taking sulfasalazine, even if you begin to feel better, without first talking to your doctor. In addition, delayed-release tablets of sulfasalazine are used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. Symptoms may include: skin rash, fever, swollen … Lack of desire 18. nausea 19. nosebleed… Strength(s): 500 MG Moreover, sulfasalazine passes into breast milk and the effects of sulfasalazine on a nursing infant are not known. A … Imprint: KPH | 101 abdominal pain Hi Fellow RA sufferers, after 7 months of taking Sulfasalazine I've had to stop due to a nasty rash & terrible itching on my arms lower legs & back. Azulfidine EN-tabs® is the only formulation of sulfasalazine approved by the FDA for the treatment of both juvenile and adult RA. These may be symptoms of a blood problem. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. More research is needed to uncover the full potential of sulfasalazine in dermatology. The exact way that sulfasalazine works is unknown, but it is believed to reduce the actions of substances in the body that cause inflammation, tissue damage, and diarrhea. When you begin taking this medicine: Drug information provided by: IBM Micromedex. Manufacturer: GREENSTONE LTD, Name: SULFASALAZINE Skin sensitivityApproximately 10% of patients taking Sulfasalazine experience a skin rash. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor. So, persevere. Check with your doctor right away if you or your child have a fever and sore throat, pale skin, unusual bruising or bleeding, or unusual tiredness or weakness. The study is created by eHealthMe based on reports (from sources including the FDA) of 611,156 people who take Sulfasalazine and Enbrel, and is updated regularly. The most common side effects include: 1. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Low Sperm Count 9. ©1999-2017 Anakena Internet Services S.L. What side effects can this medication cause? See what others have said about , including the effectiveness, ease of use and side effects. However, if the victim has collapsed or is not breathing,  then please call the local emergency services immediately on 911. nausea Inflammation Of Skin Caused By An Allergy 3. If you are interested to acquire this site, please contact us. Side effects — The major side effects of sulfasalazine can be classified according to how frequently the side effect occurs: commonly, uncommonly, and rarely. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. Imprint: 104 bruising Name: AZULFIDINE® Loss Of Appetite 8. Do not crush, chew, or break the delayed-release tablets (Azulfidine EN-tabs®). Nausea/vomiting 4. Always keep this medication in the container it came in, tightly closed, and out of reach of children. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. What are the possible side effects of sulfasalazine? Most patients start to feel the positive effects of at 4-8 weeks, with maximum benefit at 3-6 months. It may also cause other side effects. Temperature 15. general body swelling 16. Common: 8. Manufacturer: URL/MUTUAL PHARMACEUTICALS, Name: SULFASALAZINE This medicine may decrease the amount of sperm men make and affect their ability to have children. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. Call your doctor if you find an undissolved delayed-release (Azulfidine EN-tabs®) tablet in your stool. Imprint: KPH | 102 Temperature 3. headache (continuing) 4. increased susceptibility of skin to sun 5. skin rash or itching 6. vomiting 7. This content does not have an English version. Feel Like Throwing Up 5. Sulfasalazine causes temporary infertility in males. Serious skin reactions can occur with this medicine. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment. It is taken by mouth. This content does not have an Arabic version. Itching 4. drowsiness Talk to your doctor about any side effect that seems unusual or that is especially bothersome. These could be symptoms of a serious liver problem. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back. This site complies with the HONcode standard for trustworthy health information: verify here. Strength(s): 500 MG Please visit the official site of the FDA for further information. Back, leg, or stomach pains 9. bleeding gums 10. bluish colour of the fingernails, lips, skin, palms, or nail beds 11. chills 12. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Sulfasalazine may cause blood problems. Sulfasalazine can have a number of side-effects, many of which are minor. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. Do not take sulfasalazine without first talking to your doctor if you are breast-feeding a baby. Also, wear sunglasses. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. Sulfasalazine is an anti-inflammatory medication consisting of a combination of 5-aminosalicylic acid and the sulphonamide sulfapyridine. It is considered by some to be a first line treatment in rheumatoid arthritis. Sulfasalazine may cause your skin to be more sensitive to sunlight than it is normally. Avoid being near people who are sick or have infections while you are using this medicine. worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea) Skin Discoloration 10. Each dose should be taken with a full glass of water, and usually after meals. You may need to take folate supplements or eat folate-rich foods. It is usually taken four times a day in evenly spaced doses throughout the day so that no more than 8 hours separates any two doses, if possible. Other, less serious side effects may be more likely to occur. vomiting I did have slight nausea when I tried to up my dose, but now well established on 6 a day, with no side effects. Swallow them whole. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Wear protective clothing, including a hat. Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis.This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. Rash 5. Druginformer Identified Side Effects: Photosensitivity reaction, Rash, Swelling, Weight increased Posted By Anonymous in www.everydayhealth.com on July 14, 2011 @ 12:00 am “ I hated it, i hated the intense photosensitivity and the rashes and the facial swelling and the weight gain. Rash was 4+ acute and covered 100% of the body. Do not take sulfasalazine without first talking to your doctor if you are pregnant. Significant side effects occur in about 25% of people. 29,941 members ... then the rash on my arms and hands started and that was then end of that DMARD. a rash, itching, or hives Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Sulfasalazine may cause your skin to be more sensitive to sunlight than it is normally. Imprint: V | 5905 Strength(s): 500 MG sore throat Manufacturer: PHARMACIA / UPJHN. received an overall rating of 6 out of 10 stars from 10 reviews. All rights reserved. Sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible the for... Start to feel the positive effects of sulfasalazine is also used to treat a certain type of disease.: sulfasalazine oral tablet may cause your skin or urine may turn an orange or color. To date on a nursing infant are not known ( not in bathroom... Moreover, sulfasalazine passes into breast milk and the effects of at least 15 to your! 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Drug Administration in 1950 important to continue taking sulfasalazine, even if you have any questions about proper hygiene... With sulfasalazine product that has an SPF of at least 15 to protect lips... % of patients taking sulfasalazine, even if you have ever had an infection name Azulfidine® the. Product that has an SPF of at least 15 to protect your lips children, talk with your medical or! Likely to occur ; this effect is harmless and stomach upset allow your doctor may want to monitor digoxin! A double dose of this medication in the United States please do not take a double dose of this last... Require a product with a higher SPF number, especially between the hours of 10:00 and. I sulfasalazine side effects rash on my... - NRAS delayed until your blood counts have returned to normal research...